Global initiative to advance river blindness vaccine

Global initiative to advance river blindness vaccine

A cross-section of an adult female worm containing the larvae that causes river blindness.

Researchers at the University of Liverpool, together with UK and international partners, have launched a new global initiative to advance the development of a vaccine for river blindness.

Onchocerciasis, or river blindness, is a parasitic disease caused by a nematode worm and transmitted through the bite of blackflies. An estimated 17 million people are infected with more than 99% of these cases spread through 31 countries in sub-Saharan Africa.

Infections can lead to blindness, but over 70% of infected individuals will suffer from an eruptive skin disease which can be severe and debilitating, with a particularly serious negative impact on the lives of women.

Over 30 years of research

The new partnership, called The Onchocerciasis Vaccine for Africa Initiative (TOVA), involves 14 international organisations, including the University of Edinburgh, the University of Glasgow, Imperial College London and the Sabin Vaccine Institute Product Development Partnership.

The Initiative builds on over 30 years of research by partner laboratories in Africa, Europe and the United States. This involved the development of preclinical models, as well as detailed immunological investigations of human infections, which ultimately led to the identification of several protective antigens as lead vaccine candidates.

Dr Benjamin Makepeace, from the University of Liverpool’s Institute of Infection and Global Health, said: “As part of this important global initiative, we plan to take one vaccine candidate to a phase one safety trial by 2017 and phase two efficacy trials by 2020.

“Following successful trials, this would be the world’s first vaccine for this long-neglected disease and will help us eradicate the parasite from the African continent.”

Future plans

The longer-term plan is to administer an onchocerciasis vaccine to children as part of national immunisation programme.

Vaccination aims to complement the current use of a drug called ivermectin, particularly in regions where mass drug administration cannot be implemented for safety reasons, and could make a major contribution to eliminating one of the most serious public health risks for African communities.

More information on TOVA can be found in an editorial by Dr Benjamin Makepeace and colleagues and on the TOVA website.

Researchers to evaluate local green health programme

Researchers to evaluate local green health programme

Local green healthA green health and well-being programme launched in Liverpool, St Helens and Sefton will be evaluated by researchers at the University of Liverpool.

The Mersey Forest Nature4Health programme, funded by the National Lottery, plans to use the power of nature to help improve people’s minds and bodies.

The programme will include woodland walks, therapeutic gardening and practical conservation sessions to increase heart rate. It will also offer the evidence-based taught meditation technique of mindfulness in a natural setting.

Key recommendation

Dr Catrin Eames, from the University’s Institute of Psychology, Health and Society, who is part of the evaluation team, said: “Time spent in natural environments can improve physical and mental health, and is a key recommendation of the 2014 All-Party Parliamentary Group on Wellbeing Economics to improve health and wellbeing within our cities.

“By exploring the natural environment as therapeutic interventions, we can evaluate their benefits in reducing the impact of health inequality, chronic ill health and stress.

“Nature4Health is an innovative programme, with real impact within communities in accessing and developing local green space as wellbeing hubs.

“We will be working with MerseyForest to evaluate the benefits of the programme in terms of mental health and wellbeing, and particularly evaluating mindfulness-based interventions within the natural environment in enhancing and maintaining positive change and outcome. “

Healthier and happier

Paul Nolan, Director of the Mersey Forest, said: “There’s a wealth of evidence that being out in woodlands and green spaces makes us healthier and happier. This programme will enable people to enjoy their local green spaces and get fitter at the same time.”

Physical Activity Exchange at Liverpool John Moores University will also study the new programme to see how it impacts on people’s health.

Nature4Health sessions will be available in Colliers Moss, St.Helens; Mab Lane, Liverpool; Dam Wood, Croxteth Park, Liverpool; Bootle South Recreation Ground, Sefton; Rimrose Country Park, Sefton with further venues to be announced.

Closer intersectoral collaboration using existing tools can defeat zoonoses affecting humans

Closer intersectoral collaboration using existing tools can defeat zoonoses affecting humans

New WHO report urges ‘now is the time for action’

A new WHO  report urges the global community to accelerate action against neglected zoonotic diseases as most of them can be controlled through existing knowledge and tools. The report urges to accelerate action by the global community in line with World Health Assembly resolutions that provide the policy framework to act collectively against these diseases.

The report acknowledges the momentum generated over the past decade and highlights the need to focus on operations for those neglected zoonoses included in the WHO Roadmap on neglected tropical diseases.

The international community must rise up and take responsibility in pushing ahead for the control and elimination of these neglected zoonotic diseases,” said Dr Bernadette Abela-Ridder, Team Leader, Neglected Zoonotic Diseases, WHO Department of Control of Neglected Tropical Diseases. “These infections affect mainly poor segments of populations that interact closely with animals and our role should be to implement proven measures now that can contribute to the health and improved livelihood of affected families.”

Neglected zoonotic diseases prevail in low-resource settings worldwide where they impose a dual burden on affected communities and that of the livestock they depend upon.

WHO estimates that nearly two-thirds of all human pathogens originate from zoonoses, making it important to adopt a global ‘one-health approach’ involving veterinary and human sectors to control and prevent zoonotic pathogens. The report highlights the potential for intersectoral collaboration, particularly at the subnational level, and calls for more work to be done.

Initiatives by many governments have been endorsed by the Food and Agriculture Organization of the United Nations (FAO), the World Organization for Animal Health (OIE) and WHO and are financially supported by members of the broader international community, including the Bill & Melinda Gates Foundation, the UK Department for International Development, the European Union, the International Development Research Centre and the CGIAR (formerly known as the Consultative Group on International Agricultural Research).

We have existing knowledge and evidence that can be transformed into strategies and applied on a large-scale,” said Dr Dirk Engels, Director, Department of Control of Neglected Tropical Diseases. “We need to be able to capitalize on experience and the growing political commitment to involve other sectors, with community participation, to speed up the elimination agenda.

Achieving a world free from dog-mediated human rabies by 2030 is feasible with current tools and increased investment, as demonstrated by recent rabies success stories. However, the report notes other endemic zoonoses such as echinococcus have a low political profile, attract scant investment and are unlikely to achieve their 2020 target.

Control tools are available against fish-borne trematode infections and Taenia solium cysticercosis , now it is time to validate integrated and cost–effective programmes so that strategies can be evaluated and validated in order to reduce human suffering and loss to income and to attain WHO NTD roadmap targets.

The meeting report advocates the application of cross-sectoral approaches that require a combination of leadership and community-level engagement for greater impact. It also discusses opportunities for innovative funding mechanisms to support control outside traditional donor models. These include initiatives stemming from national bodies and the private sector.

The fourth international meeting on neglected zoonotic diseases “From Advocacy to Action” (Geneva, Switzerland, 19–20 November 2014 ) was hosted by WHO, attended by more than 120 delegates and financially supported by the European Union seventh framework programme through the ADVANZ (Advocacy for neglected zoonotic diseases) programme.

Discussions focused on increased recognition of zoonotic diseases and initiatives by national governments to mitigate their impact on citizens by implementing control programmes.

Although not specifically included in the WHO Roadmap on neglected tropical diseases, the meeting addressed other diseases such as anthrax, bovine tuberculosis, brucellosis and leptospirosis. For example, Mongolia has successfully implemented programmes for brucellosis control through a ‘One Health’ approach, but experience also shows that diminishing financial resources could put human and animal lives at risk once again. The emergence of brucellosis during the current war in the Syrian Arab Republic has illustrated the importance of conflict as a driver for the emergence of such a disease as people rely more on their animals for sustenance.

Many countries provided examples of programmes that are advancing control of some neglected zoonoses, both at national and local levels, from across three continents. There is now an important opportunity to mobilize existing knowledge, experience and political will, and move from advocacy to action.

WHO’s 2012 Roadmap on accelerating work to overcome the global impact of neglected tropical diseases and Resolution WHA66.12 adopted by the World Health Assembly in May 2013 have enhanced the visibility of neglected diseases with zoonotic components – notably rabies, cysticercosis, echinococcosis, human African trypanosomiasis, foodborne trematodiases and leishmaniasis.

Background

Much of the initial momentum for action against neglected zoonotic diseases was catalysed by the inaugural meeting on neglected zoonotic disease control in 2005. In 2008, experts met to formulate a global One Health concept to encourage an interdisciplinary, intersectoral approach across to tackle disease risks that emerge when humans and animals share a common environment.

Efforts to consolidate collaboration gained momentum in 2010 when a Tripartite Concept agreement between WHO, the FAO and the OIE was established. Enhanced advocacy and multisectoral collaboration have since added to the knowledge and experience for a more concerted intersectoral approach.

To view the original post on the World Health Organization website Click here

Kenyan perspective

Kenya has launched a rabies elimination strategy, as outlined in the Strategic Plan for the Elimination of Human rabies in Kenya, developed collaboratively by like minded ministries coordinated by the Zoonotic Diseases Unit.

“The medical costs associated with treatment after a person has been bitten by a rabid dog is estimated at US$170.00 in Kenya,” says James Macharia, Cabinet Secretary for Health. “This represents considerable financial hardship to a poor household.”~adopted from the WHO website

The contribution by ZED group

The new Zoonoses in Livestock in Kenya (ZooLink) project is the newest activity by the ZED group that seeks to enable Kenya to develop an effective surveillance programme for zoonoses , which is, by design, integrated across both human and animal health sectors. To achieve this goal we will work in close collaboration with Kenyan government departments, working in western Kenya initially and using this as a model for a national programme. The rationale for ZooLinK is that the presence and burden of zoonoses is greatly underestimated. To learn more about the ZooLink programme visit our page by Clicking here

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View the previous reports (click image)

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Click to view the WHO report

WHO_NTZDs _post

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Snapshots from the report(click)

ZED projects funded by DFID, BBSRC, MRC, NERC, ESRC and DSTL presented to the UK Chief Scientist

ZED projects funded by DFID, BBSRC, MRC, NERC, ESRC and DSTL presented to the UK Chief Scientist

Sir Mark Walport, the UK Chief Scientific Advisor, and representatives of the UK Department for Business, Innovation and Skills, visited the International Livestock Research Institute in Nairobi, Kenya, on Wednesday 15 July 2015.  The visit to the country was, in part, to understand UK scientific investments in Kenya; ILRI is a major recipient of UK Government funding for livestock and health research.  Two of the ZED group’s flagship projects, Urban Zoo and ZooLinK, are funded by the UK Research Councils (BBSRC, MRC, NERC, ESRC, DSTL and the Department of International Development – DFID), and as such, were presented to Sir Mark by Prof Eric Fèvre in a scientific session during his visit to ILRI.  In addition, Dr Tim Robinson (Urban Zoo and ZooLinK co-PI) presented a framework for studying antimicrobial drug resistance in domestic livestock populations.

Lets take a  glimpse at Sir Marks Visit at ILRI with a warm reception from the ZED group

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Sir Mark taking a tour around ILRI

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Prof. Eric presenting ZED group flagship projects

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Dr. Tim presenting on antimicrobial resistance

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Sir Mark keenly following the presentations

Pictures credited to ILRI

UK Government Chief Scientific Adviser (Prof Sir Mark Walport) to visit Nairobi

UK Government Chief Scientific Adviser (Prof Sir Mark Walport) to visit Nairobi

Prof Sir Mark WalportThe UK government’s Chief Scientific Adviser, Sir Mark Walport, will be visiting Nairobi from 14-15 July, 2015, with the aim of fostering closer UK-Kenya linkages on Higher education and research, and seeing the impact of UK-funded research in Kenya.

His visit comes at a time when the Kenyan government has committed new investment for science, technology and innovation as a key to economic growth. Kenya also occupies a strong position in Africa’s research landscape, second only to South Africa, in research and productivity and shows consistent rates of growth.

Sir Mark will visit the Global Alliance for Livestock Veterinary Medicines (GALVmed) offices on Tuesday 14 July. Part-funded by UK aid, GALVmed is a £70 million (approx Ksh11 billion) public-private partnership established to address the critical shortfall in livestock vaccines and medicines for animals. The visit will discuss GALVmed and partners’ market scale up of livestock vaccines and the regional engagement in Africa. That same evening he will host a talk and reception at the British High Commissioner’s Residence titled: “Evidence-based policy making—linking government, academia and private sector”. The reception will be the first major event where the British High Commission hosts Kenyan and UK partners in research and higher education. In attendance will be Chancellors and Vice Chancellors of many of Kenya’s universities, researchers and private sector organizations with links to academia, and representatives of other research funders. Media are invited to cover the event.

He will visit the International Livestock Research Institute (ILRI) on Wednesday 15 July. The visit will highlight the important role that UK-Africa institutional relationships can play in addressing food security issues and building capacity in African science. The UK provides funding to ILRI to develop and deploy new livestock vaccines and medicines and to increase the resilience and productivity of livestock-based farming systems.

Prof Eric Fevre from the ZED group will be presenting our team’s work on both the Urban Zoo and ZooLinK projects to Sir Mark during his visit to ILRI.  These projects are operating in Kenya and are funded by the UK Research Councils and DFID

Biography

Sir Mark Walport was appointed Government Chief Scientific Adviser (GCSA) and Head of the Government Office for Science in April 2013.

As GCSA Mark is co-chair of the Prime Minister’s Council for Science and Technology (CST).

His previous career highlights include:

  • Director of the Wellcome Trust
  • Professor of Medicine and Head of the Division of Medicine at Imperial College London
  • member of the India-UK CEO Forum and UK-India Round Table
  • member of the advisory board of Infrastructure UK
  • non-executive member of the Office for Strategic Coordination of Health Research

Mark received a knighthood in the 2009 New Year Honours List for services to medical research and was elected a Fellow of The Royal Society in 2011.

Government Chief Scientific Adviser

The Government Chief Scientific Adviser (GCSA) is responsible for:

  • providing scientific advice to the Prime Minister and members of Cabinet
  • advising the government on aspects of policy on science and technology
  • ensuring and improving the quality and use of scientific evidence and advice in government
  • leading the science and engineering profession within the Civil Service

Source: https://www.gov.uk/government/people/mark-walport

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