In Kenya and elsewhere, the antibiotic landscape for healthcare and livestock production is shaped by poor regulation and irrational drug use. There is a need for related evidence-based policy and the implementation plans for such policy. Our partnership is conducting in-depth research on antibacterial resistance in clinical and community settings to understand patterns of resistance, transmission of bacteria and their resistance determinants and genome-based studies of resistance evolution. This combines with social and economic approaches to quantify the burden of antibacterial infection, the behavioural aspects of drug prescribing and use and the risks of mixing of bacterial populations between clinical settings, the community and the food systems that link them. Our approach is to build a strong network of antibacterial surveillance to monitor microbial ecology and identify hotspots of selective pressure.
The transmission of AMR along the food value chain among people, environment and wildlife.
Project work packages
Surveillance in healthcare settings
Community-based longitudinal monitoring of ABR in livestock producers
Microbiological dynamics within the household
Microbiology and sequencing, developing robust microbiological and sequence-based approaches to quantifying bacterial diversity and drug sensitivity
Human behaviour and decision-making with respect to antibacterial drugs
This will be a partnership involving institutions from the United Kingdom, Kenya and East Africa employing a cross-disciplinary approach to understand the ecology of antimicrobial drug resistance in Kenya. The partners are as enlisted below:
- University of Liverpool
- International Livestock Research Institute
- Kenya Medical Research Institute
- Sanger Institute
- University of Edinburgh
- Aga Khan University, East Africa
- University of Nairobi
- Center for Disease Dynamics, Economics & Policy
- FAO ECTAD Kenya
- Ministry of Health, Kenya
- Department of Veterinary Services, Kenya
This work is funded by the UK Cross Council Initiative on Antimicrobial Resistance in a Global Context, a call led by the Medical Research Council and UK Department of Health (https://www.mrc.ac.uk/funding/browse/antimicrobial-resistance-in-a-global-context1/antimicrobial-resistance-in-a-global-context-a-cross-council-call-in-partnership-with-the-department-of-health/).